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COPD is an inflammatory lung disease, comprising several conditions, including chronic bronchitis and emphysema, and can be caused by genetics and irritants like smoke or pollution

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This aberrant immune response is characterized by airway eosinophilia, goblet cell hyperplasia, airway wall remodeling, and production of allergen-specific IgE, all driven by T helper (Th)2-derived cytokines, such as interleukin (IL)-4, IL-5, and IL-13